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Cayman Chemical RoflumIlast 10mg
Supplier: Cayman Chemical 1514110 MG
A PDE4 inhibitor (IC50 = 0.8 nM); selective for PDE4 over PDE1, -2, -3, and -5 (IC50s = >10, >10, >10, and 8 µM, respectively); inhibits fMLP-induced LTB4 production in isolated human neutrophils (IC50 = 2 nM); reduces the proliferation of anti-CD3 and anti-CD28-stimulated isolated human CD4+ T cells (IC30 = 7 nM); prevents pulmonary inflammatory cell infiltration and emphysema in mice exposed to cigarette smoke at 5 mg/kg
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