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Medchemexpress LLC Roflumilast-d4 N-Oxide | 1794760-31-8 | C17H10D4Cl2F2N2O4 | 1 MG
Supplier: Medchemexpress LLC HY15455S11MG
Roflumilast-d4 N-Oxide is a deuterium-labeled form of Roflumilast, which is a selective PDE4 inhibitor. It exhibits IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3, or PDE5 isoenzymes from various cells.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process
- Deuteration is notable for its potential to impact the pharmacokinetic and metabolic profiles of drugs
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