Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Romidepsin (FK228, depsipeptide) 128517-07-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A81735.1
Romidepsin (FK228 depsipeptide CAS 128517-07-7) is a small-molecule inhibitor targeting histone deacetylases (HDACs) Initially isolated from Chromobacterium violaceum romidepsin preferentially inhibits class I enzymes HDAC1 and HDAC2 over class II HDAC4 and HDAC6 Inhibition of HDAC activity by romidepsin results in increased histone acetylation promoting transcriptional activation of tumor suppressor genes Mechanistically this compound can trigger cellular differentiation cell-cycle arrest apoptosis and altered gene expression in various malignancies Romidepsin serves as a research tool to investigate epigenetic regulation and has notable anticancer properties in cell models such as neuroblastoma and cutaneous T-cell lymphoma
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?