This product is a recombinant, Fc-tagged ROR1 protein derived from human HEK293 cells, encompassing the identical Gln 30 to Glu 403 amino acid sequence found in human, cynomolgus, and rhesus macaque species. ROR1, also known as NTRKR1, is a transmembrane receptor kinase with critical roles in embryonic development and tumor-cell growth signaling. This protein features a C-terminal human IgG1 Fc tag and has been verified by MALS to ensure structural and purity standards.
- Greater than 90% purity by SDS-PAGE and ≥95% by SEC-MALS
- Endotoxin levels <1.0 EU per μg
- Calculated molecular weight of 68.6 kDa, migrating at 79-95 kDa due to glycosylation
- Lyophilized from a 0.22 μm filtered solution in Tris, glycine, arginine, and NaCl (pH 7.5) with trehalose
- Validated activity via ELISA and BLI binding assays