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Medchemexpress LLC Rosabulin | 501948-05-6 | 98.7% | 400.45 | 100 MG
Supplier: Medchemexpress LLC HY14934100MG
Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. It exhibits broad-spectrum anti-tumor activity.
- Potent and orally active microtubule inhibitor.
- Inhibits microtubule assembly.
- Demonstrates broad-spectrum anti-tumor activity.
- Exhibits substantial anti-proliferative activity against a wide range of cancer cell lines in vitro, including hematologic and solid tumor cell lines (leukemia, lymphoma, breast, colon, uterine) with IC50 values in the nanomolar range.
- Cell lines with multi-drug resistant (MDR) phenotypes are similarly sensitive.
- Has shown in vivo activity in several murine tumors and human tumor xenograft models, including drug-resistant tumors, when dosed orally or intravenously.
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