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Cayman Chemical Rosiglitazone, 122320-73-4, 10 mg
SDP

Supplier:  Cayman Chemical 7174010

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A thazolidinedione agonist of PPARγ; binds to the LBD of PPARγ (Kd = 43 nM); selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 μM; activates full-length PPARγ1 and PPARγ2 in a reporter assay (EC50s = 30 and 100 nM, respectively); induces differentiation of C3H10T1/2 stem cells to adipocytes at 1 μM; decreases HbA1c and fasting blood glucose levels in a rat model of type 2 diabetes induced by STZ and a high-carbohydrate/high-fat diet at 4 mg/kg; inhibits increases in contusion volume, macrophage infiltration and activation of microglia, and expression of IL-6, MCP1, ICAM1, caspase-3, and Bax in mouse cerebral cortex in a model of traumatic brain injury induced by controlled cortical impact at 6 mg/kg

Catalog No. NC9898568


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