STEMCELL Technologies Rosiglitazone, Size: 10 mg

Supplier:  STEMCELL Technologies 72622

Rosiglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM (Lehmann et al.). It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC₅₀ values of approximately 30 nM and 100 nM, respectively (Lehmann et al.).MAINTENANCE AND SELF-RENEWAL· Stimulates embryonic mouse neural stem cell proliferation and inhibits neuronal differentiation (Wada et al.). DIFFERENTIATION· Induces adipocyte differentiation in C3H10T1/2 stem cells (Lehmann et al.).· Promotes endothelial differentiation, and inhibits smooth muscle differentiation, in angiogenic progenitor cells (Wang et al.).· Stimulates adipocyte differentiation, and decreases osteogenesis, in mouse and human bone marrow-derived mesenchymal stem cells (Ali et al.; Benvenuti et al.; Lecka-Czernik et al.; Sorocéanu et al.).· Enhances osteoclast formation in mouse bone marrow cells stimulated with RANKL and M-CSF (Wu et al.).

Catalog No. 50-197-5951