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Medchemexpress LLC Roslin 2 bromide | 29574-21-8 | 99.0% | C13H19BrN4 | 1 MG
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Supplier:  Medchemexpress LLC HYA02801MG

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Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that exhibits anticancer effects. It functions by binding to FAK, thereby disrupting the interaction between FAK and p53.

  • Decreases cancer cell viability and clonogenicity in a p53-dependent manner.
  • Increases p53 transcriptional activity, which is inhibited by FAK, using p21, Mdm-2, and Bax-promoter targets.
  • Leads to increased expression of p53 targets: p21, Mdm-2, and Bax proteins.
  • Significantly reduces tumor growth, disrupts the FAK and p53 complex, and up-regulates p21 in HCT116 p53+/+ xenografts (not in HCT116 p53-/- xenografts).

Catalog No. 50-004-33446


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