Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 501687383

AdipoGen Rotenone (1 g)
SDP

Supplier:  AdipoGen AGCN20516G001

Encompass_Preferred

Rotenone (1 g), Adipogen Life Sciences. Chemical. CAS: 83-79-4. Formula: C23H22O6. MW: 394.4. Synthetic. Originally isolated from Lonchocarpus nicou. Cell-permeable reversible and competitive mitochondrial electron transport chain complex I (NADH-CoQ reductase) inhibitor (IC50=1.7-2.2µM). Inhibits NADH/DB oxidoreductase and NADH oxidase and consequently oxidative phosphorylation (OXPHOS). Specifically inhibits NAD-linked substrate oxidation of NADH dehydrogenase. Useful agent for immunometabolism research. Inhibition of electron transport chain in mitochondria leads to blocking of the transfer of electrons from iron-sulfur centers in complex I to ubiquinone. This interferes with NADH during the creation of usable cellular energy (ATP), and Complex I is unable to pass off its electron to CoQ, creating a back-up of electrons within the mitochondrial matrix.

Catalog No. 50-168-7383


May include imposed supplier surcharges.
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.