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Medchemexpress LLC Rotigotine Hydrochloride | 125572-93-2 | 99.5% | C19H26ClNOS | 100 MG
Supplier: Medchemexpress LLC HYA0007100MG
Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of the dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. It exhibits Ki values of 0.71 nM for the dopamine D3 receptor, 4-15 nM for D2, D5, and D4 receptors, and 83 nM for the dopamine D1 receptor.
- Full agonist at dopamine receptors, partial agonist at 5-HT1A receptor, and antagonist at α2B-adrenergic receptor.
- Shows selectivity for D3 receptors (10-fold over D2, D4, D5, and 100-fold over D1).
- Functionally acts as a full agonist at all dopamine receptors.
- Decreases THir neurons in primary mesencephalic cell culture.
- Neuroprotective effects against MPP+ toxicity and rotenone-induced cell death.
- Inhibits ROS production by rotenone.
- For research use only.
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