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Medchemexpress LLC Rotigotine Hydrochloride | 125572-93-2 | 99.5% | C19H26ClNOS | 25 MG
Supplier: Medchemexpress LLC 25MGHYA0007
Rotigotine Hydrochloride (N-0923 Hydrochloride) is a potent chemical that functions as a full agonist of dopamine receptors, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. It exhibits high selectivity for dopamine D3 receptors and is intended for research use only.
- Exhibits Ki values of 0.71 nM for the dopamine D3 receptor.
- Shows Ki values of 4-15 nM for D2, D5, and D4 receptors.
- Has a Ki value of 83 nM for the dopamine D1 receptor.
- Acts as a full agonist at all dopamine receptors.
- Decreases the number of THir neurons by 40% in primary mesencephalic cell culture.
- Protects dopaminergic neurons against MPP+ toxicity and rotenone-induced cell death.
- Inhibits ROS production by rotenone.
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