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AdipoGen Rottlerin (10 mg)
Supplier: AdipoGen AGCN20526M010
Chemical. CAS: 82-08-6. Formula: C30H28O8. MW: 516.5. Anticancer agent that can inhibit cell growth, induce apoptosis, autophagy and cell cycle arrest, inhibit cell invasion and shows anti-angiogenic activity. OXPHOS inhibitor. Mitochondrial uncoupler that depolarizes the mitochondrial membrane potential, reduces cellular ATP levels, activates 5'-AMP-activated protein kinase (AMPK) and affects mitochondrial production of reactive oxygen species (ROS). Useful for immunometabolism research. Potent activator of multiple Ca2+-sensitive K+ channels. Naturally occurring hERG channel activator. Antioxidant and ROS scavanger. Might have cardioprotective effects. Has been widely used as a selective inhibitor of protein kinase Cdelta (PKCdelta) (IC50=3-6µM), although there has been controversy in the literature over this claim. Inhibits CAM kinase III and a wide range of other kinases and non-kinase proteins in vitro.
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