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Apexbio Technology LLC Rotundine 483-14-7 200mg
Supplier: Apexbio Technology LLC B3676200
Rotundine (CAS 483-14-7) also known as levo-tetrahydropalmatine (l-THP) is an isoquinoline alkaloid derived from plant species such as Stephania and Corydalis Pharmacologically l-THP acts as an antagonist at both D1 and D2 dopamine receptors exhibiting higher affinity for D1 (Ki 124 nM IC50 166 nM) than for D2 receptors (Ki 388 nM IC50 1 4 M) In vivo studies have shown that l-THP reduces spontaneous locomotor activity and operant responses in rodents in a dose-dependent manner Clinically approved in China l-THP is under investigation for its non-opioid analgesic properties and potential therapeutic utility in central nervous system-related disorders and substance use research
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