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Medchemexpress LLC RP-1664 | 2980682-00-4 | 98.77% | 514.55 | 5 MG
Supplier: Medchemexpress LLC HY1727375MG
RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. It demonstrates selectivity over related kinases like AURKA/B and PLK1. This compound disrupts centriole biogenesis in cancer cells, leading to an accumulation of PLK4 and p21 protein. RP-1664 shows increased sensitivity in TRIM37-high-expressing cells or tumors and exhibits anti-tumor activity in breast cancer and neuroblastoma research.
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