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Medchemexpress LLC RP-1664 | 2980682-00-4 | 98.8% | 514.55 | 25 MG
Supplier: Medchemexpress LLC 25MGHY172737
RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. It demonstrates high selectivity over related kinases like AURKA/B and PLK1. This compound disrupts centriole biogenesis in cancer cells, leading to an accumulation of PLK4 and p21 protein. RP-1664 shows increased sensitivity in TRIM37-high-expressing cells or tumors and exhibits anti-tumor activity in breast cancer and neuroblastoma research.
- Selective and orally active PLK4 inhibitor.
- IC50 of 3 nM for PLK4.
- Exhibits exquisite selectivity over related kinases such as AURKA/B and PLK1.
- Disrupts centriole biogenesis in cancer cells.
- Leads to accumulation of PLK4 and p21 protein.
- Demonstrates increased sensitivity in TRIM37-high-expressing cells or tumors.
- Exhibits anti-tumor activity in breast cancer and neuroblastoma research.
- Appearance: Solid, White to off-white.
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