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Medchemexpress LLC RP-64477 | 135239-65-5 | 99.6% | 498.72 | 50 MG
SDP

Catalog No. 5000394136
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RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).

  • Potent ACAT inhibitor with IC50 values ranging from 6 to 283 nM in various animal tissue preparations, and 113 to 503 nM in human cell lines (HepG2, CaCo-2, and THP-1).
  • No inhibitory activity was observed against rat PCEH or LCAT at concentrations up to 200 μM and 20 μM, respectively.
  • Administration of RP-64477 significantly reduced plasma cholesterol levels in cholesterol/cholic acid-fed rats.

Catalog No. 50-003-94136 Supplier Medchemexpress LLC Supplier No. HY1643750MG
May include imposed supplier surcharges.
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RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).

  • Potent ACAT inhibitor with IC50 values ranging from 6 to 283 nM in various animal tissue preparations, and 113 to 503 nM in human cell lines (HepG2, CaCo-2, and THP-1).
  • No inhibitory activity was observed against rat PCEH or LCAT at concentrations up to 200 μM and 20 μM, respectively.
  • Administration of RP-64477 significantly reduced plasma cholesterol levels in cholesterol/cholic acid-fed rats.

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