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Medchemexpress LLC Rp-8-Br-cAMPS sodium | 925456-59-3 | 446.15 | 500 UG
Supplier: Medchemexpress LLC HY137640C500UG
Rp-8-Br-cAMPS sodium is an analog of cAMP and an inhibitor of PKA. It occupies cAMP binding sites on PKA type I regulatory subunits, which prevents PKA dissociation and activation. It can be used in the study of tumors and retrovirus-induced immune deficiency, and it also inhibits insulin secretion.
- Blocks the ability of 2-chloroadenosine to inhibit LAK cytotoxicity.
- Significantly reduces the inhibitory effect of 2-chloroadenosine on cytokine production.
- Inhibits insulin secretion in 832/13 cells.
- Improves immune function in a mouse retrovirus infection model.
- Strongly increases responses to the anti-CD3 mAb.
- Improved T cell responses.
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