Invitrogen™ Human RPS6KA2 (RSK3), GST Tag Recombinant Protein

Catalog No.	Quantity
A31522	1 mg
A31518	100 μg

Catalog No. A31522 Supplier Invitrogen™ Supplier No. A31522

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. The purified recombinant full-length protein can be used in a number of different applications, but it has been specifically validated for use with both the LanthaScreen™ & Z'-LYTE™ Assay technologies to identify novel kinase inhibitors. RPS6KA2 is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the LanthaScreen & Z'-LYTE assay technology Available in multiple pack sizes for convenient use Also available in our SelectSceen Kinase Profiling Service Protein Form: Full Length, Recombinant, Active The gene accession number for RPS6KA2 (RSK3) is NP_066958.2.

RPS6KA2 (RSK3) serine/threonine kinase is a member of the ribosomal S6 kinase (RSK) family. It is believed that RPS6KA2 is a signal-transducing intermediate in the cellular response to several growth factors. It is found in many tissues, but in higher levels in lung and skeletal muscle. The p90 ribosomal S6 kinases (RSK)1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin-Lowry syndrome, which is characterized by mental retardation and growth deficits and may have a tonic regulation on G-protein coupled signaling.

Specifications

• Accession Number: Q15349
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris HCl with 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol, 10mM glutathione, 150mM NaCl and no preservative; pH 7.5
• Gene ID (Entrez): 6196
• Molecular Weight (g/mol): 109.9 kDa
• Name: Human RPS6KA2 (RSK3), GST Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 1 mg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: 90 kDa ribosomal protein S6 kinase 2; 90kDa; D17Wsu134e; HU-2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1C; MAPKAPK1C; MAPKAPK-1c; mitogen-activated protein kinase-activated protein kinase 1C; p90rsk; p90-RSK 2; p90RSK2; p90-RSK3; pp90rsk; pp90RSK3; Protein-tyrosine kinase Mpk-9; ribosomal protein S6 kinase A2; ribosomal protein S6 kinase alpha 2; ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase polypeptide 2; ribosomal protein S6 kinase, 90kD, polypeptide 2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; ribosomal protein S6 kinase, polypeptide 2; ribosomal S6 kinase 3; Rps6ka2; Rps6ka-rs1; RSK; Rsk3; RSK-3; S6K-alpha; S6K-alpha 2; S6K-alpha2; S6K-alpha-2
• Common Name: RSK3
• Gene Symbol: RPS6KA2
• Kinase Family: RSK (RPS6K) Kinases
• Protein Length: Full Length
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: Full length
• Content And Storage: Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
  
  Store at -80°C. Upon first use, aliquot and store at -80°C to avoid multiple freeze/thaws.
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Form: Full Length, Recombinant, Active
• Form: Liquid
• Research Category: Drug Development