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RR688 Mouse Anti-Human IgG3, BD OptiBuild™

Catalog No. BDB774010 Shop All BD Biosciences Products
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50 μg
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BDB774010 50 μg
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Catalog No. BDB774010 Supplier BD Biosciences Supplier No. 774010
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Description

Mouse Monoclonal Secondary Antibody

Monoclonal Antibody Specifically detects in Human Samples. It is validated for Flow Cytometry.

The HP6050 monoclonal antibody specifically recognizes the subclass of human Immunoglobulin G (IgG) known as IgG3. Human IgG3 is the third most abundant of the four subclasses of IgG (IgG1, IgG2, IgG3, and IgG4). It consists of two identical heavy chains encoded by IGHG3 and two light chains (Igκ or Igλ) linked by disulfide bonds. The HP6050 antibody binds to the hinge region of the IgG3 heavy chain and does not cross-react with other immunoglobulin heavy chain (IgH) subclasses. IgG3 is typically expressed by plasmablasts, plasma cells, and memory (IgG3 class-switched) B cells, as well as some myeloma or plasmacytoma cells. HP6050 binds to soluble human IgG3, cytophilic IgG3 attached to Fc receptor-positive cells through its Fc region, or human IgG3 antibodies specifically bound to antigens. IgG3 can cross the placenta and diffuse throughout extravascular fluids. Human IgG3 performs multiple functions, including serving as an antigen receptor for B lymphocytes in its transmembrane form, and participating in effector functions like antibody-dependent neutralization of toxins or microbial infection, opsonization for phagocytosis, efficient complement fixation, and cell-mediated cytotoxicity in its secreted soluble forms.
TRUSTED_SUSTAINABILITY

Specifications

Applications Flow Cytometry
Classification Monoclonal
Clone HP6050 (also known as CC4-DC10)
Concentration 0.2 mg/mL
Conjugate RR688
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias IGHG3; Ig gamma-3 chain C region; Immunoglobulin heavy constant gamma 3
Host Species Mouse
Immunogen Human IgG3 myeloma protein
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Secondary
Gene ID (Entrez) 3502
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to the dye under optimum conditions that minimize unconjugated dye and antibody.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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