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Apexbio Technology LLC RS 127445 199864-87-4 5mg
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Supplier:  Apexbio Technology LLC A37785

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RS 127445 (CAS 199864-87-4) is a highly selective antagonist of the serotonin 5-HT2B receptor displaying nanomolar affinity (pKi 9 5 pIC50 10 4) and approximately 1000-fold selectivity over other receptor subtypes By inhibiting 5-HT2B-mediated signaling RS 127445 suppresses serotonin-induced increases in inositol phosphate and intracellular calcium in cellular models In vivo administration in rat models reduces stress- and TNBS-induced visceral hypersensitivity and attenuates colonic motility responses RS 127445 is widely used to elucidate 5-HT2B receptor functions in neurogastroenterology and mechanisms of gastrointestinal hypersensitivity

Catalog No. 50-000-96500


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