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Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 10 MM * 1 ML
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Supplier:  Medchemexpress LLC HY1541910MM/1ML

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RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. It exhibits 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites. This product is intended for research use only.

  • Selective and high affinity 5-HT2B receptor antagonist.
  • Exhibits 1000-fold selectivity for the 5-HT2B receptor.
  • Orally bioavailable.
  • Potently displaces [3H]-5-HT from human recombinant 5-HT2B receptors.
  • Blocks 5-HT-evoked increases in intracellular calcium.
  • Antagonizes 5-HT-evoked formation of inositol phosphates.
  • Dose-dependently reduces faecal output in rats.

Catalog No. 50-003-76560


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