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Cayman Chemical RS 127445hydrochlorIde 10mg
SDP

Supplier:  Cayman Chemical 2345110 MG

Encompass_Preferred

A 5-HT2B receptor antagonist (Ki = 0.32 nM); selective for 5-HT2B over other 5-HT receptor subtypes (Ki = >3 μM for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT3, 5-HT5, and 5-HT6); reduces contraction of rat isolated stomach fundus (pA2 = 9.5) and 5-HT-induced increases in intracellular calcium (IC50 = 0.04 nM); blocks (±)-α-methyl-5-HT-induced relaxation of isolated rat jugular veins (pA2 = 9.95); reduces peristaltic frequency and fecal output in mice in a dose-dependent manner; reduces basal, but not cocaine-induced, dopamine outflow in the nucleus accumbens of rats; decreases cocaine- or quinpirole-induced hyperlocomotion in rats

Catalog No. 50-298-7932


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