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Cayman Chemical RS 17053hydrochlorIde 10mg
SDP

Supplier:  Cayman Chemical 3354810 MG

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An α1A-AR antagonist; selectively binds to the α1A-AR (Ki = 2.5 nM) over α1B-and α1D-ARs (Kis = 50 and 79 nM, respectively); inhibits norepinephrine-induced contractions in isolated rat kidney and mesenteric arteries (pA2s = 9.8 and 9.9, respectively) and, to a lesser extent, in isolated rat aortic rings and human lower urinary tract tissue (pA2s = 7.7 and 7.3, respectively); inhibits phenylephrine-induced increases in MAP in normotensive and spontaneously hypertensive rats (ED50s = 528 and 533 UG/kg, respectively)

Catalog No. 50-294-6509


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