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Apexbio Technology LLC RSL3, 10mg CAS# 1219810-16-8
Supplier: Apexbio Technology LLC B609510
IC50: 100 nMRSL3 (1S,3R-) is the inhibitor of the glutathione peroxidase 4.Maintaining cellular redox balance is critical for cell survival and tissue homoeostasis since imbalanced production of reactive oxygen species results in oxidative stress and cell death. The antioxidant enzyme glutathione peroxidase 4 is a important regulator of oxidative stressinduced cell death.In vitro: RSL3, which was a glutathione peroxidase (GPX) 4 inhibitor, had been cooperated with the Smac mimetic BV6 to induce reactive oxygen species (ROS)-dependent cell death in acute lymphoblastic leukemia cells. It was found that addition of the caspase inhibitor failed to rescue ROS-induced cell death, suggesting that RSL3-induced cell death occured in a caspase-independent manner. Other sizes are also available. Please inqury us for quote.
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