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Cayman Chemical Mifepristone, 84371-65-3, 100 mg
SDP

Supplier:  Cayman Chemical 10006317100

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Molecular Formula C29H35NO2, Purity ≥98%, Formula Weight 429.6, Synonyms: RU-486; An antagonist of glucocorticoid, progesterone, and androgen receptors (Kis = 0.1, 0.64, and 0.65 nM, respectively); selective for these receptors over MR, ER, and ER (Kis = 640, >200, and >750 nM, respectively); inhibits R5020-stimulated alkaline phosphatase activity as well as reporter transcription stimulated by either dexamethasone or R5020 in cell-based assays (IC50s = 7, 5.9, and 1.3 nM, respectively); inhibits R1881-stimulated reporter transcription in a concentration-dependent manner; inhibits growth of 4-OHT-resistant MCF-7 breast cancer cells in vitro at 10 M; inhibits tumor growth in an SKOV3 ovarian cancer nude mouse xenograft model at 0.5 or 1 mg per day.

Catalog No. NC9988828


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