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Medchemexpress LLC RU-521 | 2262452-06-0 | 100.0% | 415.23 | 50 MG
SDP

Supplier:  Medchemexpress LLC 50MGHY114180

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RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor. It inhibits cGAS-mediated interferon upregulation and suppresses dsDNA-activated reporter activity.

  • Inhibits cGAS-mediated interferon upregulation.
  • Suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM.
  • Reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).
  • Reduces symptoms from sepsis in mice, increasing cardiac function and decreasing inflammatory responses.

Catalog No. 50-003-65947


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