Cayman Chemical RupIntrIvIr 10mg

Supplier:  Cayman Chemical 4154310 MG

An inhibitor of HRV 3C protease; inhibits HRV 3C protease-induced proteolysis of HRV-14 precursor polyproteins in HRV-14-infected H1HeLa cells at 2 µM; inhibits replication of 49 serotypes of HRV in HRV-infected H1HeLa cells (mean EC50 = 0.023 µM); inhibits replication of coxsackievirus 21, coxsackievirus B3, echovirus type 11, and enterovirus 70 in virus-infected MRC-5 cells (EC50s = 0.147, 0.183, 0.014, and 0.007 µM, respectively); decreases the number of HRV-2 PFUs in, and IL-8 and IL-6 secretion by, HRV-2-infected BEAS-2B cells at 10 µM; inhibits enterovirus 71-induced limb paralysis and decreases in survival, as well as reduces intestinal, lung, brain stem, and cardiac muscle viral loads, in enterovirus-71-infected neonatal mice at 0.1 mg/kg per day

Catalog No. 50-294-4213