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Apexbio Technology LLC Ruthenium Red 100mg
Supplier: Apexbio Technology LLC B6740100
Ruthenium Red (CAS 11103-72-3) is a potent inhibitor of calcium (Ca ) transport across biological membranes including mitochondrial erythrocyte and rabbit skeletal muscle sarcoplasmic reticulum membranes It acts by blocking Ca uptake at specific binding sites one high-affinity site (K sub m /sub 4 5 M) and one lower-affinity site (K sub m /sub 2 0 mM) associated with the Ca -ATPase transmembrane domain Incubation of sarcoplasmic reticulum vesicles with micromolar concentrations of Ruthenium Red significantly reduces Ca binding capacity Additionally Ruthenium Red suppresses capsaicin-induced plasma extravasation in rat trachea in a dose-dependent manner This compound is widely used to investigate Ca signaling transport mechanisms and neurogenic inflammation in biomedical research
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