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Cayman Chemical Ruxolitinib, 941678-49-5, 1 mg
SDP

Supplier:  Cayman Chemical 116091

Encompass_Preferred

A potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively; blocks IL-6 signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM); reduces splenomegaly, decreases circulating levels of IL-6 and TNF-α, eliminates neoplastic cells, and prolongs survival in a mouse model of JAK2V617F+ MPN

Catalog No. NC0541702


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