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Apexbio Technology LLC Ruxolitinib (INCB018424) 941678-49-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A30125.1
Ruxolitinib (INCB018424 CAS 941678-49-5) is a small-molecule inhibitor targeting Janus kinases JAK1 and JAK2 Structurally categorized as a cyclopentylpropionitrile derivative it functions via ATP-competitive inhibition of JAK1 and JAK2 kinase activities thereby suppressing downstream phosphorylation events involving STAT5 and ERK1/2 By impairing these signaling pathways ruxolitinib can reduce cellular proliferation It is widely researched in oncology particularly in studies analyzing its therapeutic potential in myeloproliferative disorders including myelofibrosis and conditions involving oncogenic JAK2 fusion proteins
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