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Medchemexpress LLC Ruxolitinib phosphate | 1092939-17-7 | MFCD18452860 | 99.97% | C17H21N6O4P | 200 MG
SDP

Supplier:  Medchemexpress LLC HY50858200MG

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Ruxolitinib phosphate (INCB018424 phosphate) is a potent JAK1/2 inhibitor with IC50s of 3.3 nM for JAK1 and 2.8 nM for JAK2, demonstrating over 130-fold selectivity compared to JAK3. It potently and selectively inhibits JAK2V617F-mediated signaling and proliferation in vitro, inhibiting the growth of HEL cells with an EC50 of 186 nM and increasing apoptosis in Ba/F3-EpoR-JAK2V617F cells.

  • Potent and selective JAK1/2 inhibitor
  • Inhibits JAK2V617F-mediated signaling and proliferation
  • Increases apoptosis in specific cell systems
  • Inhibits hematopoietic progenitor cell proliferation in MPN patient samples

Catalog No. 50-003-58180


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