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Medchemexpress LLC RWJ-56110 dihydrochloride | 2387505-58-8 | 99.9% | 863.65 | 25 MG
Supplier: Medchemexpress LLC 25MGHY108556A
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. It inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), demonstrating selectivity relative to U46619. This compound also blocks angiogenesis, the formation of new vessels in vivo, and induces cell apoptosis.
- Potent and selective PAR-1 inhibitor.
- Inhibits human platelet aggregation.
- Blocks angiogenesis and new vessel formation.
- Induces cell apoptosis.
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