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RY743 Mouse Anti-Human IgG1, BD OptiBuild™

Catalog No. BDB773001 Shop All BD Biosciences Products
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50 μg
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BDB773001 50 μg
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Catalog No. BDB773001 Supplier BD Biosciences Supplier No. 773001
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Description

Mouse Monoclonal Secondary Antibody

Monoclonal Antibody Specifically detects in Human Samples. It is validated for Flow Cytometry.

The HP6001 monoclonal antibody specifically recognizes the subclass of human Immunoglobulin G (IgG) known as IgG1. Human IgG1 is the most abundant of the four subclasses of IgG found in human serum followed by IgG2, IgG3 and IgG4. IgG1 is comprised of two identical heavy chains encoded by IGHG1 and two light chains, either Igκ or Igλ, linked by disulfide bonds. The HP6001 antibody binds to the CH2 domain of the IgG1 heavy chain and does not crossreact with other immunoglobulin heavy chain (IgH) subclasses. IgG1 is normally expressed by plasmablasts, plasma cells, and memory B cells as well as by some myeloma or plasmacytoma cells. HP6001 binds to soluble human IgG1, cytophilic IgG1 attached to cells through its Fc region, or human IgG1 antibodies specifically bound to antigens. IgG1 can cross the placenta and disseminate in extravascular fluids throughout the body. Human IgG1 serves multiple functions with the transmembrane form serving as an antigen receptor for B lymphocytes and secreted soluble forms participating in various effector functions. The latter include antibody-dependent neutralization of toxins or infection by microbes, opsonization for phagocytosis, complement fixation, and cell-mediated cytotoxicity.
TRUSTED_SUSTAINABILITY

Specifications

Applications Flow Cytometry
Classification Monoclonal
Clone HP6001 (also known as FB5-EEI2)
Concentration 0.2 mg/mL
Conjugate RY743
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias IGHG1; IgG1 (Fc); Immunoglobulin gamma 1; Immunoglobulin heavy constant gamma 1
Host Species Mouse
Immunogen Purified Human Immunoglobulins
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Secondary
Gene ID (Entrez) 3500
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to the dye under optimum conditions that minimize unconjugated dye and antibody.
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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