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RY775 Mouse Anti-Human IgM, BD OptiBuild™

Catalog No. BDB772237 Shop All BD Biosciences Products
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BDB772237 50 μg
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Catalog No. BDB772237 Supplier BD Biosciences Supplier No. 772237
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Description

Mouse Monoclonal Secondary Antibody

Monoclonal Antibody Specifically detects in Human Samples. It is validated for Flow Cytometry.

The UCH-B1 monoclonal antibody specifically recognizes the heavy chain constant region (Cμ) of human Immunoglobulin M (IgM) encoded by IGHM. It does not cross-react with other immunoglobulin heavy or light chain isotypes. Intracytoplasmic IgM is expressed by pre-B cells, while immature and some mature B cells (naive and memory B cells) express cell surface IgM. These IgM forms can also be expressed by cells from certain leukemias or lymphomas. Cell surface IgM consists of two type I transmembrane Igμ heavy chains paired with either immunoglobulin kappa (Igκ) or lambda (Igλ) light chains. It functions as a receptor for antigens, triggering clonal expansion and differentiation of B cells into antibody-secreting plasma cells. A soluble pentameric form of IgM, composed of 5 monomers (each with two Igμ heavy chains and two light chains complexed with a J-chain), is secreted into the blood by plasma cells. The UCH-B1 monoclonal antibody recognizes both cell surface and soluble human IgM. IgM is crucial in the initial defense against foreign pathogens and may also be involved in autoimmune diseases. The UCH-B1 antibody has been reported to activate or co-stimulate proliferation of normal B cells or some transformed B cell lines.
TRUSTED_SUSTAINABILITY

Specifications

Applications Flow Cytometry
Classification Monoclonal
Clone UCH-B1 (also known as UCHB1)
Concentration 0.2 mg/mL
Conjugate RY775
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias UCHB1; IGHM; MU
Host Species Mouse
Immunogen Human Prolymphocytic Leukemia B Cells
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Secondary
Gene ID (Entrez) 3507
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to the dye under optimum conditions that minimize unconjugated dye and antibody.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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