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Medchemexpress LLC (S)-(-)-Bay-K-8644 | 98625-26-4 | C16H15F3N2O4 | 1 MG
SDP

Catalog No. 5000374998
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(S)-(-)-Bay-K-8644 is an agonist of the L-type Ca2+ channel, activating Ba2+ currents (IBa) with an EC50 of 32 nM. This specific isomer acts as an agonist, differentiating it from the antagonist effects of its R(+) counterpart. It can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in guinea pig antrum gastric myocytes and enhances Ca2+ channel activity at concentrations of 3-30 μM. It also inhibits contractile responses in rat tail artery strips and increases whole-cell Ca2+ currents in A7r5 smooth muscle cells.

  • Acts as an agonist of L-type Ca2+ channel.
  • Activates Ba2+ currents with an EC50 of 32 nM.
  • Prevents inhibitory actions of cyclic nucleotide pathways on IBa.
  • Enhances Ca2+ channel activity at 3-30 μM.
  • Inhibits contractile responses caused by FPL 64176.
  • Increases whole-cell Ca2+ currents in A7r5 smooth muscle cells.

Catalog No. 50-003-74998 Supplier Medchemexpress LLC Supplier No. HY151241MG
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(S)-(-)-Bay-K-8644 is an agonist of the L-type Ca2+ channel, activating Ba2+ currents (IBa) with an EC50 of 32 nM. This specific isomer acts as an agonist, differentiating it from the antagonist effects of its R(+) counterpart. It can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in guinea pig antrum gastric myocytes and enhances Ca2+ channel activity at concentrations of 3-30 μM. It also inhibits contractile responses in rat tail artery strips and increases whole-cell Ca2+ currents in A7r5 smooth muscle cells.

  • Acts as an agonist of L-type Ca2+ channel.
  • Activates Ba2+ currents with an EC50 of 32 nM.
  • Prevents inhibitory actions of cyclic nucleotide pathways on IBa.
  • Enhances Ca2+ channel activity at 3-30 μM.
  • Inhibits contractile responses caused by FPL 64176.
  • Increases whole-cell Ca2+ currents in A7r5 smooth muscle cells.

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