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AdipoGen S-Gboxin iodide (5 mg)
SDP

Supplier:  AdipoGen AGCR13533M005

Encompass_Preferred

Chemical. CAS: 2101317-21-7. Formula: C27H32F3N2O2 . I. MW: 473.6 . 126.9. Synthetic. Potent mitochondrial ATP synthase (ATPases (F0F1)) inhibitor, consequently leading to inhibition of oxidative phosphorylation (OXPHOS). Useful agent for immunometabolism research. Inhibits ATP synthase by blocking its proton channel (F0 subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production), significantly reducing electron flow through the electron transport chain. Potent antitumor agent that inhibits oxidative phosphorylation and consequently growth and proliferation of mouse and human glioblastoma (GBM) with an IC50 of 470nM. Shown to rapidly and irreversibly compromise oxygen consumption in glioblastoma cells. This functional Gboxin analog has excellent metabolic stability, enhanced plasma stability and pharmacokinetic properties, and is suitable for in vivo studies.

Catalog No. 50-205-3925


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