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Apexbio Technology LLC (S)-Mephenytoin 70989-04-7 5mg
Supplier: Apexbio Technology LLC C34145
(S)-Mephenytoin (CAS 70989-04-7) is an anticonvulsant compound recognized as a probe substrate for the cytochrome P450 isoform CYP2C19 which catalyzes its 4-hydroxylation and N-demethylation CYP2C19-mediated metabolism of (S)-Mephenytoin serves as an archetype for studying genetic polymorphisms affecting drug oxidation in humans In vitro the Km for (S)-Mephenytoin hydroxylation is reported as 1 25 mM with Vmax values between 0 8 and 1 25 nmol/min/nmol P450 in the presence of cytochrome b5 This compound is widely used in research to evaluate CYP2C19 enzymatic activity and to investigate inter-individual differences in drug metabolism
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