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Medchemexpress LLC S-Methylisothiourea sulfate | 867-44-7 | MFCD00013055 | 99.9% | C2H6N2S.1/2H2O4S | 100 MG
Supplier: Medchemexpress LLC HY79457100MG
S-Methylisothiourea sulfate is a potent, selective, and competitive inhibitor of inducible nitric oxide synthase (iNOS). It has shown beneficial effects in rodent models of septic shock.
- Acts as a competitive inhibitor of iNOS activity at the L-arginine site.
- Prevents NO-mediated cytotoxic effects of LPS in cultured macrophages.
- Inhibits LPS-induced nitrite production in macrophages and rat aortic vascular muscle cells.
- Reverses hypotension and vascular hyporeactivity caused by endotoxin LPS in anesthetized rats.
- Attenuates increases in plasma aminotransferases, bilirubin, and creatinine.
- Improves survival rates in mice treated with high doses of LPS.
- Restores blood pressure and inhibits iNOS activity in lung homogenates of LPS-treated rats.
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