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Medchemexpress LLC S-Methylisothiourea sulfate | 867-44-7 | MFCD00013055 | 99.9% | C2H6N2S.1/2H2O4S | 100 MG
SDP

Catalog No. 5000433064
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S-Methylisothiourea sulfate is a potent, selective, and competitive inhibitor of inducible nitric oxide synthase (iNOS). It has shown beneficial effects in rodent models of septic shock.

  • Acts as a competitive inhibitor of iNOS activity at the L-arginine site.
  • Prevents NO-mediated cytotoxic effects of LPS in cultured macrophages.
  • Inhibits LPS-induced nitrite production in macrophages and rat aortic vascular muscle cells.
  • Reverses hypotension and vascular hyporeactivity caused by endotoxin LPS in anesthetized rats.
  • Attenuates increases in plasma aminotransferases, bilirubin, and creatinine.
  • Improves survival rates in mice treated with high doses of LPS.
  • Restores blood pressure and inhibits iNOS activity in lung homogenates of LPS-treated rats.

Catalog No. 50-004-33064 Supplier Medchemexpress LLC Supplier No. HY79457100MG
May include imposed supplier surcharges.
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S-Methylisothiourea sulfate is a potent, selective, and competitive inhibitor of inducible nitric oxide synthase (iNOS). It has shown beneficial effects in rodent models of septic shock.

  • Acts as a competitive inhibitor of iNOS activity at the L-arginine site.
  • Prevents NO-mediated cytotoxic effects of LPS in cultured macrophages.
  • Inhibits LPS-induced nitrite production in macrophages and rat aortic vascular muscle cells.
  • Reverses hypotension and vascular hyporeactivity caused by endotoxin LPS in anesthetized rats.
  • Attenuates increases in plasma aminotransferases, bilirubin, and creatinine.
  • Improves survival rates in mice treated with high doses of LPS.
  • Restores blood pressure and inhibits iNOS activity in lung homogenates of LPS-treated rats.

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