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Medchemexpress LLC (S,R)-GSK321 | 1816272-18-0 | 98.6% | 10 MG
Supplier: Medchemexpress LLC HY128888B10MG
(S,R)-GSK321 is a potent and selective mutant IDH1 inhibitor, specifically the (S,R)-enantiomer of GSK321. It demonstrates high selectivity over IDH2 and induces a decrease in intracellular 2-HG. This compound abrogates the myeloid differentiation block and promotes granulocytic differentiation in leukemic blasts and immature stem-like cells. It is suitable for research into acute myeloid leukemia (AML) and other cancers.
- Potent, selective mutant IDH1 inhibitor
- IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively
- Greater than 100-fold selectivity over IDH2
- Induces a decrease in intracellular 2-HG
- Abrogates the myeloid differentiation block
- Induces granulocytic differentiation in leukemic blasts and immature stem-like cells
- Used for research of acute myeloid leukemia (AML) and other cancers
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