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Medchemexpress LLC (S,R)-GSK321 | 1816272-18-0 | 98.6% | 100 MG
Supplier: Medchemexpress LLC HY128888B100MG
(S,R)-GSK321 is the (S,R)-enantiomer of GSK321. It is a potent, selective mutant IDH1 inhibitor with IC50 values for R132G, R132C, R132H, and WT IDH1, and exhibits >100-fold selectivity over IDH2. (S,R)-GSK321 induces a decrease in intracellular 2-HG, abrogation of the myeloid differentiation block, and induction of granulocytic differentiation. It can be used for research of acute myeloid leukemia (AML) and other cancers.
- Potent, selective mutant IDH1 inhibitor
- Induces a decrease in intracellular 2-HG
- Abrogation of myeloid differentiation block
- Induction of granulocytic differentiation
- Useful in research for acute myeloid leukemia (AML) and other cancers
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
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