Sigma Aldrich (S,R,S)-Ahpc Hydrochloride

Catalog No.	Quantity
90-149-0100MG	25 mg

Catalog No. 90-149-0100MG Supplier Sigma Aldrich Supplier No. 901490100MG

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

(S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487) used as a negative control.Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC™ Degraders for Targeted Protein DegradationStructure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar AffinitiesModular PROTAC Design for the DegradationofOncogenic BCR-ABLSelective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

• CAS: 2140807-17-4
• Molecular Formula: C14H13N3O4
• Linear Formula: C14H13N3O4
• Quantity: 25 mg
• Synonym: 4-Amino-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; E3 Ligase ligand methylated negative control; Ligand for PROTAC(R) research
• Molecular Weight (g/mol): 287.27 g/mol