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Sigma Aldrich (S,R,S)-Ahpc-Peg2-Butyl Co2H

Catalog No. 91060050MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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91-060-050MG 50 mg
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Catalog No. 91-060-050MG Supplier Sigma Aldrich Supplier No. 91060050MG
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Protein degrader builiding block (S,R,S)-AHPC-PEG2-butyl CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Technology Spotlight: Partial PROTACs for Targeted Protein DegradationBuilding PROTAC™ Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACsPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

CAS 290490-29-6
Molecular Formula C20H26N4O4 -+ xHCl
Quantity 50 mg
Synonym 7-Amino-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)heptanamide hydrochloride; C5 Lenalidomide conjugate; Crosslinker-E3 Ligase ligand conjugate; Protein degrader building block for PROTAC(R) research; Template for synthesis of targeted protein degrader
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