Sigma Aldrich (S R S)-Vl285 Phenol

Catalog No.	Quantity
92-090-8100MG	50 mg

Catalog No. 92-090-8100MG Supplier Sigma Aldrich Supplier No. 920908100MG

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

(S,R,S)-VL285 Phenol is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology, providing an alternative to the widely used VH032 (901490).(S,R,S)-VL285 Phenol-linker conjugates are also available for synthesis of degraders. Browse our full offering of degrader building blocks that streamlines the synthesis of degrader libraries.Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC™ Degraders for Targeted Protein DegradationHaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion ProteinsSystematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degradersDesign, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic propertiesDifferential PROTAC substrate specificity dictated by orientation of recruited E3 ligasePROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

• Molecular Formula: C42H51N7O6S -+ xHCl
• Linear Formula: C42H51N7O6S -+ xHCl
• Quantity: 50 mg
• Synonym: (2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)-2-((6-(3-(piperazin-1-yl)propoxy)pyridin-3-yl)methoxy)benzyl)pyrrolidine-2-carboxamide; Crosslinker-E3 Ligase ligand conjugate; VHL protein degrader building block for PROTAC(R) research