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Sigma Aldrich (S,S,S)-Ahpc Hydrochloride

Catalog No. 901487100MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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90-148-7100MG 10 mg
90-148-710MG 5 g
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

(S,S,S)-AHPC (HCl salt) is a ligand used as a negative control for (S,R,S)-AHPC (cat# 901490) in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC™ Degraders for Targeted Protein DegradationSelective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4Small-Molecule PROTACS: New Approaches to Protein DegradationIdentification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

CAS 191732-72-6
Quantity 10 mg
Synonym (2S,4S)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride; E3 Ligase ligand negative control epimer; Ligand for PROTAC(R) research; VH032 negative control
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