Medchemexpress LLC S-Trityl-L-cysteine | 2799-07-7 | 98.99% | 363.47 | 100 MG

Supplier:  Medchemexpress LLC HYW011102100MG

S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor, demonstrating an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. This compound also exhibits antitumor activities.

• Selective and allosteric kinesin Eg5 inhibitor.
• Inhibits basal ATPase activity with an IC50 of 1 μM.
• Inhibits microtubule-activated ATPase activity with an IC50 of 140 nM.
• Possesses antitumor activities.
• Binds to a unique pocket within the Eg5 motor domain.
• Mediates cell apoptosis and cell cycle arrest in a dose-dependent manner (1-20 μM for 72 hours).
• Triggers apoptosis and cell cycle arrest through the activation of mitogen-activated protein kinase and nuclear factor kB signaling pathways.
• Induces mitotic arrest in HeLa cells (IC50 of 700 nM), leading to characteristic monoastral spindles.

Catalog No. 50-004-51871