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Medchemexpress LLC S1ra (hydrochloride) | 1265917-14-3 | 99.9% | 373.88 | 250 MG
Supplier: Medchemexpress LLC 250MGHY18099A
S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. It demonstrates good selectivity against σ2R (Ki >1000 nM). This compound is also identified as a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride has been shown to inhibit neuropathic pain and activity-induced spinal sensitization.
- Orally active and selective sigma-1 receptor (σ1R) antagonist
- High affinity for human and guinea pig σ1Rs
- Good selectivity against sigma-2 receptors (σ2R)
- Acts as a human 5-HT2B receptor antagonist
- Inhibits neuropathic pain
- Reduces activity-induced spinal sensitization
- Demonstrates analgesic effects on formalin-evoked nociceptive behaviors in mice
- Reverses capsaicin-induced mechanical hypersensitivity in mice
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