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Medchemexpress LLC S2101 | 1239262-36-2 | 99.7% | 311.76 | 1 ML
SDP

Catalog No. 5000343928
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S2101 is a lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 0.99 μM, Ki of 0.61 μM, and Kinact/Ki of 4560 M/s. It exhibits lower inhibition activity toward MAO-B (Ki=17 μM, Kinact/Ki=18 M/s) and MAO-A (Ki=110 μM, Kinact/Ki=60 M/s). Treatment of HEK293T cells with S2101 leads to a dose-dependent increase in H3K4me2 levels, indicating LSD1 inactivation. It is approximately 50-fold stronger in LSD1 inhibition activity than 2-PCPA in human cells.

  • Potent and selective inhibition of LSD1
  • Lower inhibition activity toward MAO-B and MAO-A
  • Induces dose-dependent increase in H3K4me2 levels
  • Approximately 50-fold stronger LSD1 inhibition than 2-PCPA in human cells

Catalog No. 50-003-43928 Supplier Medchemexpress LLC Supplier No. HY110277100MG
May include imposed supplier surcharges.
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S2101 is a lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 0.99 μM, Ki of 0.61 μM, and Kinact/Ki of 4560 M/s. It exhibits lower inhibition activity toward MAO-B (Ki=17 μM, Kinact/Ki=18 M/s) and MAO-A (Ki=110 μM, Kinact/Ki=60 M/s). Treatment of HEK293T cells with S2101 leads to a dose-dependent increase in H3K4me2 levels, indicating LSD1 inactivation. It is approximately 50-fold stronger in LSD1 inhibition activity than 2-PCPA in human cells.

  • Potent and selective inhibition of LSD1
  • Lower inhibition activity toward MAO-B and MAO-A
  • Induces dose-dependent increase in H3K4me2 levels
  • Approximately 50-fold stronger LSD1 inhibition than 2-PCPA in human cells

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