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Cayman Chemical S49076hydrochlorIde 10mg
Supplier: Cayman Chemical 4117310 MG
A multi-kinase inhibitor; inhibits c-Met, Axl, Mer, FGFR1, FGFR2, and FGFR3 (IC50s = 1, 7, 2, 18, 17, and 15 nM, respectively); inhibits Axl- and c-Met-mediated Akt phosphorylation in MDA-MB-231 cells (IC50s = 33 and 50s = 50-200 nM); reduces mean tumor volume in GTL-16 and U87MG mouse xenograft models from 6.25-50 mg/kg
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