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Medchemexpress LLC S65487 hydrochloride | 1644543-95-2 | 99.7% | 753.72 | 1 ML
Supplier: Medchemexpress LLC HY138697B10MM/1ML
S65487 hydrochloride (VOB560 hydrochloride) is a potent and selective Bcl-2 inhibitor, acting as a proagent of S55746. It is effective against BCL-2 mutations like G101V and D103Y, while showing low affinity for MCL-1, BFL-1, and BCL-XL. This compound is known to induce apoptosis and exhibits anticancer activities.
- Potent and selective Bcl-2 inhibitor.
- Proagent of S55746.
- Active against BCL-2 mutations (G101V and D103Y).
- Low affinity with MCL-1, BFL-1, and BCL-XL.
- Induces apoptosis.
- Exhibits anticancer activities.
- Induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single intravenous administration.
- Shows strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat when combined with the MCL-1-specific inhibitor S64315/MIK665.
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