Medchemexpress LLC S65487 sulfate | 2416937-01-2 | 99.35% | 815.33 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY138697A

S65487 sulfate is a potent and selective Bcl-2 inhibitor and a proagent of S55746. It is active on BCL-2 mutations like G101V and D103Y, but shows poor affinity with MCL-1, BFL-1, and BCL-XL. This compound induces apoptosis and exhibits anticancer activities.

• Potent and selective Bcl-2 inhibitor
• Proagent of a related compound
• Active on BCL-2 mutations (e.g., G101V, D103Y)
• Shows poor affinity with MCL-1, BFL-1, and BCL-XL
• Induces apoptosis in hematological cancer cell lines
• Inhibits cell proliferation with IC50s in the low nM range
• Induces complete regression in BCL-2-dependent RS4;11 tumors in vivo
• Causes strong and persistent tumor regression in xenograft models of lymphoid malignancies when combined with a MCL-1 specific inhibitor

Catalog No. 50-003-52473